Bodybuilding Anti Estrogen Steroids Formestanes Raw Lentaron Hormonal

CAS 566-48-3 Formestanes Raw Lentaron Hormonal Anti Estrogen Steroids for Bodybuilding

1, Quick Detail

Model NO.: 566-48-3
Customized: Customized
Suitable for: Adult
Purity: >99%
CAS Register Number: 566-48-3
Delivery: EMS, UPS, FedEx, DHL etc
Policy: Re-Shipping Policy
Delivery Time: 5-7 Working Days
Factory Supply: Yes
Transport Package: Foil Bag or as You Required
Origin: China
Powder: Yes
Certification: GMP, HSE, ISO 9001, USP, BP
State: Solid
Product Name: Formestanes
Payment Terms: Western Union, , T/T
Supply Ability: 1000kg/Month
Export Markets: Global.
Factory Price: Yes
Specification: GMP, ISO 9001, USP, BP
HS Code: 2942000000
Molecular Formula: C19h26o3
Molecular Weight: 302.41

2, Description

Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane suppresses estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor.

3, Applications

Formestanes is a second generation, irreversible, steroidal aromatase inhibitor. It inhibits the aromatase enzyme responsible for converting androgens to estrogens, thereby preventing estrogen production. Breast cancer may be estrogen sensitive or insensitive. A majority of breast cancers are estrogen sensitive. Estrogen sensitive breast cancer cells depend on estrogen for viability.

Thus removal of estrogen from the body can be an effective treatment for hormone sensitive breast cancers. Formestanes has been targeted specifically for the treatment of postmenopausal women. Unlike premenopausal women who produce most estrogen in the ovaries, postmenopausal women produce most estrogen in peripheral tissues with the help of the aromatase enzyme.

4, Dosages

Formestane is indicated for the treatment of advanced breast cancer in postmenopausal women. The recommended dosage is 250 mg by intramuscular injection (buttock) every two weeks. Although not a medically approved form of the drug, studies have demonstrated that a similar level of estrogen suppression can also be achieved with oral use of formestane. Due to poor bioavailability, however, the dose needed is around 250 mg per day . When used (off-label) to mitigate the estrogenic side effects of anabolic/androgenic steroid use or increase muscle definition, male athletes and bodybuilders often take 250 mg every two weeks by injection, or 250 mg per day orally.

5, Side Effects

Common side effects associated with the use of an aromatase inhibitor include hot flashes, joint pain, weakness, fatigue, mood changes, depression, high blood pressure, swelling of the arms/legs, and headache. Aromatase inhibitors may also decrease bone mineral density, which may lead to osteoporosis and an increase in fractures in susceptible patients. Some individuals may also respond to the medication with gastrointestinal side effects including nausea and vomiting. Aromatase inhibitors can harm the development of an unborn fetus, and should never be taken or handled during pregnancy. When taken by men (as an off-label use) to reduce estrogenicity during prolonged periods of steroid treatment, aromatase inhibitors may increase cardiovascular disease (CVD) risk by retarding some beneficial properties of estrogen on cholesterol values.

Studies have demonstrated that when an aromatizable steroid such as testosterone enanthate is taken in conjunction with an aromatase inhibitor, suppression of HDL (good) cholesterol levels becomes significantly more pronounced. Since the estrogen receptor agonist/antagonist Nolvadex® generally does not display the same anti-estrogenic (negative) effect on cholesterol values, it is usually favored over aromatase inhibitors for estrogen maintenance by male bodybuilders and athletes concerned with cardiovascular health.

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Minimum Order Quantity: 10g

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