120511-73-1 Anti Estrogen Steroids Arimidex White Raw Powder Aromatase Inhibitor

 

 

Anastrozole, sold under the trade name Arimidex among others, is a medication used in addition to other treatments for breast cancer. Specifically it is used for hormone receptor-positive breast cancer. It has also been used to prevent breast cancer in those at high risk. It is taken by mouth.

 

Common side effects include hot flashes, altered mood, joint pain, and nausea. Severe side effects include an increased risk of heart disease and osteoporosis. Use during pregnancy is known to harm the baby. Anastrozole is in the aromatase-inhibiting family of medications. It works by blocking the creation of estrogen.

 

 

Anastrozole lowers the amount of oestrogen in the body. The female sex hormones oestrogen and progesterone stimulate many breast cancers to grow. Lowering the level of oestrogen can stop or slow the growth of breast cancer cells.

 

Anastrozole blocks a process called aromatisation which changes sex hormones called androgens into oestrogen. This happens mainly in the fatty tissues, muscle and the skin and needs a particular enzyme called aromatase.

 

 

Items	Standard	Results
Description	White crystalline powder	Complies
Identification	IR HPLC Reactive	Conform with standard IR Conform with standard HPLC Conform
Solubility	Freely soluble in methanol,acetone,ethanol and tetrahydrofuran. And very soluble in acetonitrile	Complies
Total Impurity	max.0.5%	0.18%
Total Unspecified Impurity	max. 0.2%	0.08%
Individual unspecified impurlty	max. 0.1%	0.05%
Related compound B	max. 0.2%	0.07%
Related compound C	max. 0.2%	0.04%
Related compound D	max. 0.1%	0.05%
Related compound E	max. 0.1%	0.06%
Limit of cyclohexane	max. 0.08%	ND
Limit of ethylacetate	max. 0.1%	0.07%
Melting point	81.0~84.0	82.5~83.2
Water	max. 0.3%	0.21%
Residue on ignition	max. 0.1%	0.07%
Heavy Metals	max.0.001%	Complies
Assay(HPLC)	98.0%~102.0%	99.8%
Storage	Cool and dry

 

 

Treating certain types of breast cancer in women who have been through menopause, including women with disease progression after tamoxifen therapy. It may also be used for other conditions as determined by your doctor.

 

Anastrozole is an aromatase inhibitor. It works by lowering blood estradiol concentrations, which may decrease the size and growth of the tumor.

 

 

Anastrozole is a tablet that is taken by mouth. You can take this medication with or without food. Your health care team will tell you how much medication you should take. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not take two dosses at the same time. Do not stop taking anastrozole without talking to your healthcare team. If you take too much medication, notify your health care team or go to the emergency room immediately.

 

Be sure to tell your healthcare team about all medications you take before starting anastrozole, including over the counter medications, vitamins and herbal supplements. You should not take this medication if you are currently taking tamoxifen, or other medications that include estrogen, including hormone replacement therapy, birth control pills, estrogen creams, vaginal ring and vaginal suppositories.