Fat Burn Supplements Steroids Raw powder Local Anesthetic Drugs Lidocaine /

 

 

Lidocaine, also known as xylocaine and lignocaine is a medication used to numb tissue in a specific area and to treat ventricular tachycardia.] It can also be used for nerve blocks. Lidocaine mixed with a small amount of adrenaline (epinephrine) is available to allow larger doses for numbing, to decrease bleeding, and to make it last longer. When used as an injectable, it typically begins working within four minutes and lasts for half an hour to three hours.Lidocaine may also be applied directly to the skin for numbing.

 

Common side effects with intravenous use include sleepiness, muscle twitching, confusion, changes in vision, numbness, tingling, and vomiting. It can cause low blood pressure and an irregular heart rate. There are concerns that injecting it into a joint can cause problems with the cartilage. It appears to be generally safe for use in pregnancy. A lower dose may be required in those with liver problems. It is generally safe to use in those allergic to tetracaine or benzocaine. Lidocaine is an antiarrhythmic medication of the class Ib type. Lidocaine works by blocking sodium channels and thus decreasing the rate of contractions of the heart. When used locally as a numbing agent, local neurons cannot signal the brain

 

 

Test Items	Specification	Result
Characters	White crystalline powder with characteristic odor	White crystalline powder with weak odor
Melting point	66 degree to 70 degree	66.6 degree-68.5 degree
Identification	BCDE Conforms with the requirement	Conforms
Appearance of solution	Clear and colorless	Conforms
Water	Not more than 0.5%	0.3%
Sulphate	Not more than0. 1%	Conforms
Chloride	Not more than 0. 0035%	0.0025%
Heavy Metals	Not more than 0.002%	0.001%
Residue on Ignition	Not more than 0.1%	0.02%
Impurity (26-dimethylaniline content)	Not more than 0.01%	Conforms
Assay (HPLC)	99.0%-101.0%	99.6%
Conclusion	Conforms BP 2007 Standard

 

 

The efficacy profile of lidocaine as a local anaesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anaesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for spinal and epidural anaesthesias; lidocaine, though, has the advantage of a rapid onset of action. Adrenaline vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anaesthesia, several formulations can be used for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local numbing less painful. Lidocaine drops can be used on the eyes for short ophthalmic procedures.

 

There is tentative evidence for topical lidocaine for neuropathic pain.

 

 

 

2% viscous solution: Gargle 15 mL, undiluted, and spit out or swallow, no less than every 3 hours

Maximum dose: 300 mg for normal healthy adult - not to exceed 4.5 mg/kg (2 mg/lb), or 8 doses in 24 hours

 

Comments:

-Adjust dose based on patients age, weight, and physical condition.

 

Uses:

-Topical anesthesia of irritated or inflamed mucous membranes of the mouth and pharynx

-Reducing gagging during dental x-rays and impressions